ADM-SIO

SIO History

SIO’s beginnings date back to 1907, and today, is one of the most important global pharmaceutical oil manufacturer.

As a subsidiary of Archer Daniels Midland Company since 1996, our company manufactures state-of-the-art purified pharmaceutical oils that can be used as APIs or as excipients for oral, topical and injectable formulations of oil-soluble drugs. With more than a century of experience in the manufacture of specialty oils, we also offer the best ingredients of vegetable origin for various applications in human and animal nutrition (e.g. hydrogenated vegetable oils for encapsulation) and cosmetic industries (e.g. high melting point vegetable oils and butters).

On the below historical timeline, you have an overview on the major steps that made ADM-SIO become a key player in the supply of lipid-based pharmaceutical ingredients:

ADM-SIO

SIO Locations

Our 125 employees are spread over two sites:

Our manufacturing site and laboratory are located in Saint-Laurent-Blangy, in the north of France.

The Executive Management as well as the Sales and Marketing departments are based in Fourqueux, in the Paris region.

With our experience in the manufacture of specialty oils, we are able to deliver the best lipid-based solutions anywhere on the globe.

Worldwide Presence

Since its creation in 1907, ADM-SIO has been able to adapt its strategy and product portfolio to fast-moving trends and challenges within specialty oils industry.

Today, we aim at positioning ADM-SIO as a major player for the use of purified oils and esters, as active ingredients or excipients in the pharmaceutical industry, while seeking opportunities with high added value products in the food and feed sectors.

Below is an overview of ADM-SIO business coverage, with presence on all continents:

In green the countries where ADM-SIO delivers its products.

For more information, please visit: https://www.admsio.com/en/home-page/

Purified Pharmaceutical Oils

SIO Excipients

These highly purified oils (pharmaceutical soybean oil, pharmaceutical olive oil and pharmaceutical sesame oil) can be used as excipients in both human health (propofol, hormones, vitamins) and animal health applications (veterinary uses).

They are useful in the formulations of soft gels capsules, as solubilizer for API’s insoluble in water (Cyclosporin, Dronabinol, Cannabidiol, etc.) and as texturizers. They can also be used in various syrups and lotions.

ADM-SIO highly purified oils meet all the regulations in the pharmaceutical industry and are manufactured under cGMP standards.

You will find below our list of products:

Regulatory Conformity

Submitted Regulatory Files

In order to meet our customers’ requirements, we have submitted the following regulatory files (Active Substance Master File or DMF) to Health agencies:

SIO Quality Standards

At ADM-SIO, we produce highly purified pharmaceutical oils. Our production and quality control system fulfill the ICH-Q7 GMP requirements for active pharmaceutical ingredients. A 9-step purification process is applied to the starting materials to deliver high quality pharmaceutical vegetable oils. Final steps of the process, including fine filtration and drum filling under nitrogen are performed in an ISO 8 classified cleanroom.

The high purity, strict quality and compliance with GMP requirements, make our purified pharmaceutical oils fully suitable for use in injectable applications (as API or excipient) and also for oral or topical formulations.

Hydrogenated Vegetable Oils

Range of products

High melting point vegetable oils

ADM-SIO offers a wide range of fully hydrogenated vegetable oils that can be used in the pharmaceutical, food, feed and cosmetic industries. They are produced from refined vegetable oils and offer a cost-effective and sustainable alternative to paraffin and other mineral products.

We are able to manufacture a wide range of melting points and crystallization behaviors to perfectly answer your needs and expectations.

You will find hereafter our range of hydrogenated vegetable oils:

Applications

Use in Food and Cosmetic industries

Our hydrogenated vegetable oils are produced and sold as fat flakes (overview on picture). They can be used in various applications.

In human nutrition for example, they are used as texturizing agents for gum bases (chewing gum), spreads and marinades.

In cosmetics, our high melting point vegetable oils are good alternatives to microcrystalline waxes. They can also provide hydrating function and deliver protecting and regenerating properties to vegetable butters and waxes. In all cases, our hydrogenation process guarantees the stability of your formulations and our team ensure you to have the best answer to your needs.

Conditioning

We sell our hydrogenated vegetable oils in 25kg paper bags or in 600kg big bags.

Certifications and Quality

Our products are FAMI QS certified, which allows us to deliver lipid-based solutions respecting the best manufacturing practices in the feed industry.

At ADM-SIO, quality is our top priority. Our ingredients come from carefully selected and non-GMO raw materials. They are manufactured under strict quality assurance conditions in accordance with ISO 9001: 2015 and HACCP methods.

Contract Manufacturing & Other Lipid-based Solutions

Customized refining (special oils, GMP)

Our product development team is available to work with you to meet your specific needs.

We currently have two production lines: a line dedicated to the refining of pharmaceutical oils under GMP conditions and a line dedicated to the refining of special oils.

For each order, we ask our customers to consider a minimum lot of 5T.

Esterification

Solid Fatty Esters

Resulting from the esterification between a fatty acid cut and a fatty alcohol cut, we are able to synthesize solid fatty esters to answer our customers’ specific needs.

Our products are used in pharmaceutical (excipients) and dermo-cosmetic applications.

Hydrogenation

Hydrogenated vegetable oils

Beyond our range of hydrogenated vegetable oils, we are able to hydrogenate (total or partial hydrogenation) your vegetable oils based on your own specifications.

Customized products manufactured for our customers are usually used in the following applications:

Texturizing agent for lipstick and lip balm,
Viscosity generator for skin care products and color cosmetics,
Substitute for microcrystalline waxes.

Nutritional and functional blends

Nutritional blends

These blends may consist of fluid oils with (or without) additives such as vitamins or antioxidants. They respond to a specific fatty acid profile for applications in clinical and infant nutrition.

At ADM-SIO, quality is our priority. Our ingredients come from carefully selected and non-GMO raw materials. They are manufactured under strict quality assurance conditions in accordance with ISO 9001: 2015 and HACCP.

Functional Blends

Solid fats at room temperature, these may be butters or other vegetable fats used in the manufacturing process of pastries, sweets or breads.

For every project, we aim at delivering vegetable fats that perfectly match the needs of our customers.

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