Antares Vitamin E TPGS has a record of safety based on decades of use in humans and animals and on reported toxicology studies. It is safe for transportation, storage and handling. Vitamin E TPGS has a self-affirmed GRAS (Generally Recognized As Safe) status when used as an oral dietary supplement of vitamin E.

Antares Vitamin E TPGS solubilizes, emulsifies, and enhances the absorption of difficult to absorb lipophilic APIs in a wide range of pharmaceutical dosage forms and drug delivery systems. This ensures your drug will work as though it has high potency API.

Advantages of Antares Vitamin E TPGS as an Emulsifying Agent in Pharmaceuticals:

• Available in NF grade

• Versatile, functional excipient with proven success in oral (solids and liquids), topical, ocular, mucosal and parenteral delivery

• Long history (over 50 years) of safe use

• Effective at Solubilizing and/or emulsifying a wide range of water-immiscible, lipid, and poorly-soluble APIs (also see reference 1 below).

• Possesses all the characteristics of an effective emulsifier: is water-soluble, has amphiphilic molecular structure, a low critical micelle concentration (CMC), and creates a large surface area of oil it disperses in water

• Forms physically / chemically / thermodynamically stable micelle and other liquid crystalline phase structures in water and oil / water systems and can serve as a carrier or matrix component in drug delivery / controlled release systems (references 2 and 3 below).

• Enhances the absorption and bioavailability of poorly soluble APIs in malabsorbing patients due to several key qualities : its emulsifying / solubilizing properties and its ability to form micelles (also see references 4 and 5 below).

• Supplies natural d-α-tocopherol in water-soluble form. It is universally accepted that the natural form of vitamin E, d-α-tocopherol, is more potent than the synthetic form of vitamin E, dl-α-tocopherol. The breadth of this acceptance extends throughout the industry and includes the Food and Drug Administration (FDA) and the National Academy of Sciences (NAS). For more information on the advantages of the natural d-α- over the synthetic dl-α- tocopherol, please see The Vitamin E Factor by Andreas Papas, PhD.